Effect of depression on cognitive decline: Is it mediated through cerebral

 
   Lead Investigator:    Aliza Wingo
   Institution      :    Emory University
   E-Mail           :    aliza.wingo@emory.edu
   Proposal ID      :    919



   Proposal Description:
   We propose to use the NAAC Uniformed dataset of participants who were             pre-morbidly assessed and subsequently underwent autopsy assessment to            investigate                                                                       2a) the relationship between depressive symptoms and rate of cognitive decline,   adjusting for AD pathological burden.                                             2b) whether rates of cognitive decline accounted for by depression are            significantly different between men and women.                                    2c) whether depression modifies the association between AD pathological burden    and cognitive decline.